Aplastic Anemia

People

Timothy Olson, MD, PhD

Photo of Timothy Olson, MD, PhD
Principal Investigator

Dr. Olson's clinical efforts focus on pediatric hematopoietic stem cell transplantation (HSCT), with a specific emphasis on HSCT for patients with inherited and acquired bone marrow failure.

Daria Babushok, MD, PhD

Photo of Daria Babushok, MD, PhD
Principal Investigator

Dr Daria Babushok is a physician-scientist and an Assistant Professor of Medicine in the Division of Hematology-Oncology at the University of Pennsylvania. Dr Babushok laboratory conducts basic and translational research focusing on the immune pathogenesis of acquired aplastic anemia and the development of clonal hematopoiesis in acquired aplastic anemia and other bone marrow failure disorders.

Joseph Oved, MD

Joseph Oved, MD
Postdoctoral Fellow

Dr. Oved is a Pediatric Hematology/Oncology fellow and a postdoctoral fellow in Dr. Timothy Olson’s laboratory. His clinical interests involve hematopoietic stem cell transplant, cell therapies and bone marrow failure. He is currently working on developing novel lentiviral gene therapies for inherited bone marrow failure conditions.

An Steensels

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Research Scientist

An has a Master of Science in Biology from the University of Leuven in Belgium, and did a master thesis project on the contributions of ARF6 and Presenillins in endosomal trafficking in Alzheimer’s Disease. After graduating in 2015, she lived in Tanzania, Spain, and Belgium, where she worked on several science and animal rescue projects. In addition, An went back to school to get a degree in Veterinary Technology.

Benjamin Frost

Photo of Benjamin Frost
Research Scientist

Ben received his Bachelor of Science degree in Chemistry from Haverford College in 2019. Before becoming a Research Specialist, Ben worked in the Comprehensive Bone Marrow Failure Center as an undergraduate, and he wrote one of his undergraduate theses on research related to acquired aplastic anemia. The scope of his research has since broadened to include other bone marrow failure disorders such as paroxysmal nocturnal hemoglobinuria.

Research

  • The role of germline genetic predisposition syndromes in the development of pediatric myelodysplastic syndrome and acute myeloid leukemia
  • Patterns of HLA allele expression and clonal evolution in acquired aplastic anemia, and how these findings may serve as biomarkers for disease response as well as clues to the underlying immune basis of this disease
  • Investigation of how intrinsic pathways governing hematopoietic stem cell niche function can be harnessed to improve the efficiency and durability of donor engraftment after hematopoietic stem cell transplantation, particularly in the context of bone marrow failure syndromes.
  • Clinical trials of novel conditioning and T cell depletion strategies to improve survival and decrease allo-immune complications for patients with non-malignant hematologic disorders undergoing hematopoietic stem cell transplantation.

The long-term goal of the Babushok Laboratory to improve the outcomes of patients with bone marrow failure disorders through bench-to-bedside research aimed at elucidating mechanisms of hematopoietic failure and transforming this knowledge into rational therapies.