Aplastic Anemia

People

Daria Babushok, MD, PhD

Photo of Daria Babushok, MD, PhD
Principal Investigator

Dr Daria Babushok is a physician-scientist and an Assistant Professor of Medicine in the Division of Hematology-Oncology at the University of Pennsylvania. Dr Babushok laboratory conducts basic and translational research focusing on the immune pathogenesis of acquired aplastic anemia and the development of clonal hematopoiesis in acquired aplastic anemia and other bone marrow failure disorders.

Timothy Olson, MD, PhD

Photo of Timothy Olson, MD, PhD
Principal Investigator

Dr. Olson's clinical efforts focus on pediatric hematopoietic stem cell transplantation (HSCT), with a specific emphasis on HSCT for patients with inherited and acquired bone marrow failure.

Joseph Oved, MD

Joseph Oved, MD
Postdoctoral Fellow

Dr. Oved is a Pediatric Hematology/Oncology fellow and a postdoctoral fellow in Dr. Timothy Olson’s laboratory. His clinical interests involve hematopoietic stem cell transplant, cell therapies and bone marrow failure. He is currently working on developing novel lentiviral gene therapies for inherited bone marrow failure conditions.

Caitlin Ritz

Photo of Caitlin Ritz
Research Technician

Caitlin Ritz received her Bachelors of Arts and Sciences in Biochemistry from the University of Colorado and completed a Post-Baccalaureate Specialized Studies Program at the University of Pennsylvania. She

Kathy Guo

Kathy Guo
Research Technician
Kathy Guo graduated from the University of Pennsylvania in 2017. After graduation, she was a research specialist in the Abramson Family Cancer Research Institute researching neuroblastoma. Kathy later joined the Comprehensive Bone Marrow Failure Center and continued under Dr. Babushok in the Department of Hematology at Penn, studying Aplastic Anemia. Kathy will be pursuing a degree in dentistry at Temple University next fall.

Natasha Stanley

Natasha Stanley
Research Technician

Natasha received her Bachelor of Science degree in Biology from Haverford College in 2015. Natasha's previous research involved tracking chloroplast inheritance in Chlamydomonas with fluorescent protein tools and studying the effects of psychiatric drug therapies on glucocorticoid receptor translocation in human olfactory epithelial cells. Natasha's studies mechanisms of clonal evolution in acquired aplastic anemia.

Research

  • The role of germline genetic predisposition syndromes in the development of pediatric myelodysplastic syndrome and acute myeloid leukemia
  • Patterns of HLA allele expression and clonal evolution in acquired aplastic anemia, and how these findings may serve as biomarkers for disease response as well as clues to the underlying immune basis of this disease
  • Investigation of how intrinsic pathways governing hematopoietic stem cell niche function can be harnessed to improve the efficiency and durability of donor engraftment after hematopoietic stem cell transplantation, particularly in the context of bone marrow failure syndromes.
  • Clinical trials of novel conditioning and T cell depletion strategies to improve survival and decrease allo-immune complications for patients with non-malignant hematologic disorders undergoing hematopoietic stem cell transplantation.

The long-term goal of the Babushok Laboratory to improve the outcomes of patients with bone marrow failure disorders through bench-to-bedside research aimed at elucidating mechanisms of hematopoietic failure and transforming this knowledge into rational therapies.