The Comprehensive Bone Marrow Failure Center (CBMFC) at The Children’s Hospital of Philadelphia (CHOP) studies the underlying mechanisms responsible for defective blood production in patients with bone marrow failure and seeks to improve the diagnosis, care and treatment of patients with inherited or acquired bone marrow failure.

The physicians in CBMFC coordinate clinical care and research in bone marrow failure to provide the best care and most current treatments available to our pediatric patients. We offer complete diagnostic, therapeutic and support services for children with acquired and inherited bone marrow disorders including: Aplastic anemia (acquired and familial), Diamond-Blackfan anemia, Dyskeratosis congenital, Fanconi anemia, Myelodysplastic syndrome, Paroxysmal noctumal hemoglobinuria, Severe congenital neutropenia, Shwachman Diamond syndrome, and other inherited bone marrow failure syndromes.

Our physicians work with a team of nurses, fellows and social workers to provide a thorough, multidisciplinary evaluation and comprehensive care. After reviewing medical records and test results and meeting with the family, we discuss the patient’s overall health, recommend necessary diagnostic evaluations and outline treatment options. We then provide the patient’s family and referring physician with a written summary that includes treatment recommendations. We also assist with prevention efforts, initiation and surveillance of treatment response, and monitoring of late complications.

Our medical and transfusion therapies have achieved results that are among the best nationally.