Olson Clinical Trial #5
TransIT Study (#16-013471, NCT02845596) Unrelated Donor Transplant versus Immune Therapy in Pediatric Severe Aplastic Anemia (Pulsiper/Williams, North American Pediatric Aplastic Anemia Consortium)
Type: Multicenter Prospective Clinical Trial (Olson Site PI)
Description: The primary objective of this study is to determine the feasibility of comparing outcomes of patients treated de novo with immunosuppressive therapy (IST) versus matched unrelated donor (MUD) hematopoietic stem cell transplant (HSCT) for pediatric acquired severe aplastic anemia. The secondary objective is to measure the time from screening consent and randomization of patients to initiation of the preparative regimen of those randomized to HSCT.