Olson Clinical Trial #2

CHP 16BT052 (IRB 16‐012881, NCT03047746) Unrelated and Partially Matched Related Donor Peripheral Stem Cell Transplant w/ TCRαβ depletion for patients with Bone Marrow Failure Syndromes

Type: Institutional Prospective Clinical Trial (Olson PI)

Status: enrolling

Description: This is a single arm pilot study using TCRαβ+ T cell-depleted peripheral blood stem cells (PBSC) from closely matched unrelated donors or partially matched/haploidentical related donors for HSCT in patients with acquired and inherited bone marrow failure syndromes. Previously established transplant preparative regimens will be selected and administered based on the specific underlying BMF condition. Mobilized PBSC will be processed using the CliniMACS system for TCRαβ+ T cell depletion plus CD19+ B cell depletion. The study will determine efficacy of this strategy in terms of engraftment, rates of acute and chronic GvHD, and one year overall and event-free survival.

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