Olson Clinical Trial #1

CHP 14BT057 (IRB 14‐011465, NCT02928991) Pilot Study of Fludarabine‐based Conditioning for Matched Related Donor Bone Marrow Transplantation in Patients with Acquired and Inherited Bone Marrow Failure Syndromes

Type: Institutional Prospective Clinical Trial (Olson PI)

Status: enrolling

Description: The primary objectives of this study include 1) determination of time to engraftment, as well as rates of primary and secondary graft failure and acute and chronic chronic graft versus host disease (GvHD) following matched related donor bone marrow transplant (MRD-BMT) for patients with acquired aplastic anemia (AA) or inherited Bone Marrow Failure (iBMF) syndromes receiving fludarabine-based conditioning regimens, and 2) defining the correlation between the degree of donor chimerism achieved following MRD-BMT in patients with acquired AA or iBMF syndromes and overall survival, graft failure, elimination of clonal hematopoiesis, and quality of immune reconstitution.