Kurre Laboratory

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With extended training in Pediatric Hematology, Oncology and Stem Cell Transplantation at Fred Hutchinson Cancer Research Center, Dr. Kurre’s clinical work is now focused on children with bone marrow failure. He strives to provide excellence in care for families and patients across a wide spectrum of inherited and acquired conditions that lead to loss of blood formation. As a Physician Scientist, both clinical and scientific goals of his work are therefore directed at improving understanding and broadening treatment options for patients with bone marrow failure.

Dr. Kurre’s clinical interests focus on diagnosis and treatment of bone marrow failure and specifically on improving diagnostic and therapeutic capabilities. Advances in genomic technologies provide exciting opportunity to streamline the frequently extended diagnostic work up of children with bone marrow failure.  He and colleagues at other institutions are spearheading efforts to leverage molecular technologies toward the development of tests that improve diagnostic certainty and timeliness of genetic bone marrow failure. They are also developing clinical trials to enhance treatment and post treatment surveillance options.

Dr. Kurre’s laboratory has longstanding expertise in Fanconi Anemia (FA), a rare inherited genetic condition with prominent hematologic complications. With a training background in transplantation and hematopoietic stem cell biology, he hopes to improve understanding of the progressive hematopoietic failure that occurs in patients with FA. In addition to preclinical vector development for stem cell gene therapy, his more recent studies aim to reveal the origins of bone marrow failure in FA before birth. Studies in murine models of FA indicate that a significant portion of hematopoietic stem cells are lost prenatally and during infancy.  The lab is developing strategies that will ameliorate those losses, with the long term goal of reversing the successive erosion of the stem cell pool in children. Additional projects in the lab are focused on stem cell regulation by trafficking of extracellular vesicles in the bone marrow microenvironment.

Dr. Kurre is also associated with the following groups:

  • Comprehensive Bone Marrow Failure Center - Director
  • Department of Pediatrics - Physician
  • Division of Hematology - Attending

Location: Abramson Research Center, ARC 303

PubMed: Peter Kurre, MD

People

Peter Kurre, MD

Photo of Peter Kurre, MD
Principal Investigator

With extended training in Pediatric Hematology, Oncology and Stem Cell Transplantation at Fred Hutchinson Cancer Research Center, Dr. Kurre’s clinical work is now focused on children with bone marrow failure. He strives to provide excellence in care for families and patients across a wide spectrum of inherited and acquired conditions that lead to loss of blood formation. As a Physician Scientist, both clinical and scientific goals of his work are therefore directed at improving understanding and broadening treatment options for patients with bone marrow failure. Dr. Kurre’s laboratory has longstanding expertise in Fanconi Anemia (FA), a genetic condition with prominent hematologic complications. With training in transplantation and hematopoietic stem cell biology, he hopes to improve our understanding of the progressive hematopoietic failure in patients with BMF and FA, and broaden diagnostic approaches, and develop next generation therapies.

Ding-Wen Chen, PhD

Ding-Wen Chen, PhD
Postdoctoral Fellow

Dr. Chen completed his PhD at the University of Waterloo in 2018 with research training at the interface of drug delivery, gene therapy, nanomedicine and regenerative medicine. As a postdoctoral fellow at Kurre’s laboratory, Dr.

Jian-Meng Fan

Jian-Meng Fan
Research Technician

Jian-Meng Fan received her BS degree of Medical Laboratory from Shanghai JiaoTong University School of Medicine. She has extensive experience and skill sets in molecular and cellular biology, hematology, telomere biology and aging. She also has strong hands-on experience and record on patient-derived cell isolation, culturing and manipulation.

Theresa Menna

Photo of Theresa Menna
Research Technician

Theresa Menna, BS, became a Research Technician for the Bone Marrow Failure Center in December 2018. Her role is to design and conduct experiments in tissue culture and mouse models to further understand the processes in hematopoietic stem cells that contribute to Fanconi Anemia.

Peter Nicholas

Peter Nicholas
Research Coordinator

Peter Nicholas joined the Bone Marrow Failure Center in June of 2010 and is currently the Study Coordinator/Lab Manager. Peter oversees all the current IRB approved studies that are open within the Bone Marrow Failure Center, and makes sure they continue to be IRB compliant.

Research

  • Understand cause of stem cell losses in Fanconi Anemia.
    • Failure of the hematopoietic system with stem cell losses is a near uniform occurrence in FA. The etiology remains unknown and we are using murine models to understand the underlying defect
  • The role of FA proteins during hematopoietic development Hematopoietic development in bone marrow failure diseases is poorly understood and fetal deficits remain to be elucidated.
    • As hematopoietic stem cells undergo maturation to an adult phenotype well after birth, therapeutic opportunities that focus on fetal characteristics may reveal additional therapeutic opportunities.
  • The role of cell-derived extracellular vesicles in stem cell regulation.
    • Cell derived vesicles are constitutively released by cells. The transmission of protein an RNA cargo to other cells in both paracrine and endocrine manner has revealed potent regulatory capacity. We are beginning to study their role in HSC regulation in several loss and gain of function models.

Publication Highlights

Chakkaramakkil Verghese S, Goloviznina NA, Kurre P. Phenotypic correction of Fanconi anemia cells in the murine bone marrow after carrier cell mediated delivery of lentiviral vector. Stem Cell Res Ther. Stem Cell Res Ther. 2016 Nov 19;7(1):170. PMID: 27865213.

Doron B, Abdelhamed S, Butler JT, Hashmi SK, Horton TM, Kurre P. Transmissible ER stress reconfigures the AML bone marrow compartment. Leukemia. 2018 Sep 11. doi: 10.1038/s41375-018-0254-2. [Epub ahead of print] PMID: 30206307.

Yoon YM, Storm KJ, Kamimae-Lanning AN, Goloviznina NA, Kurre P. Endogenous DNA Damage Leads to p53-Independent Deficits in Replicative Fitness in Fetal Murine Fancd2(-/-) Hematopoietic Stem and Progenitor Cells. Stem Cell Reports. 2016 Nov 8;7(5):840-853. doi: 10.1016/j.stemcr.2016.09.005. Epub 2016 Oct 6. PMID: 27720904.

Hornick NI, Doron B, Abdelhamed S, Huan J, Harrington CA, Shen R, Cambronne XA, Chakkaramakkil Verghese S, Kurre P. AML suppresses hematopoiesis by releasing exosomes that contain microRNAs targeting c-MYB. Sci Signal. 2016 Sep 6;9(444):ra88. doi: 10.1126/scisignal.aaf2797. PMID: 27601730.

Gagne KE, Ghazvinian R, Yuan D, Zon RL, Storm K, Mazur-Popinska M, Andolina L, Bubala H, Golebiowska S, Higman MA, Kalwak K, Kurre P, Matysiak M, Niewiadomska E, Pels S, Petruzzi MJ, Pobudejska-Pieniazek A, Szczepanski T, Fleming MD, Gazda HT, Agarwal S. Pearson marrow pancreas syndrome in patients suspected to have Diamond-Blackfan anemia. Blood. 2014 Jul 17;124(3):437-40. doi: 10.1182/blood-2014-01-545830. Epub 2014 Apr 15. PMID: 24735966.

Articles

Postdoctoral Fellow Opening

Monday, February 4, 2019 Full Article: view

A Postdoctoral position in Hematopoietic Stem Cell Biology is available in the laboratory of Peter Kurre, M.D., at the Comprehensive Center for Bone Marrow Failure. The Laboratory has longstanding expertise in hematopoietic stem cell biology and has actively investigated stem cell losses in Fanconi Anemia (FA) for over a decade. Ongoing work is focused on fetal stem cell losses in murine models of FA and their contribution to the stem cell exhaustion and leukemogenesis that are a hallmark of FA. Investigations will involve a wide range of methods in stem cell and molecular biology, imaging and bioinformatics. The postdoctoral fellow will, under the direction/guidance of a mentor, Peter Kurre, MD, assume responsibility for a specific, on-going research project.