Dr Daria Babushok is a physician-scientist and an Assistant Professor of Medicine in the Division of Hematology-Oncology at the University of Pennsylvania. Dr Babushok laboratory conducts basic and translational research focusing on the immune pathogenesis of acquired aplastic anemia and the development of clonal hematopoiesis in acquired aplastic anemia and other bone marrow failure disorders.
Comprehensive Bone Marrow Failure Center
The Comprehensive Bone Marrow Failure Center (CBMFC) at The Children’s Hospital of Philadelphia (CHOP) serves patients with inherited or acquired bone marrow failure. We provide comprehensive consultation and treatment across a range of bone marrow failure disorders.
The center brings together CHOP experts from all relevant pediatric subspecialties and is closely affiliated colleagues at the Hospital of the University of Pennsylvania caring for adult BMF patients. Across all age groups, physicians and researchers provide state of the art diagnostics clinical care, as well as investigational studies for many inherited and acquired bone marrow failure conditions. We have extensive experience in caring for patients with Aplastic anemia (acquired and familial), Diamond-Blackfan anemia, Dyskeratosis congenital, Fanconi anemia, Myelodysplastic syndrome, Paroxysmal noctumal hemoglobinuria, Severe congenital neutropenia, Shwachman Diamond syndrome, and other inherited bone marrow failure syndromes.
As a team, physicians, nurses, fellows, language interpreters and social workers work to provide patients, families and referring providers with multidisciplinary evaluations. Consultation begins before the patient visit with a review of medical records and prior test results, followed by meeting with the family, patient evaluation. A comprehensive recommendation provides family and provider with suggestions for additional diagnostic evaluations and outlines treatment options. Clinical services thrive on and seamless transition between ambulatory and inpatient care and our treatment outcomes rank among the best nationally. We facilitate any family counseling and assist with prevention efforts, initiation and surveillance of treatment response, and monitoring of late complications.
Center physicians and researchers collaborate extensively with other national and international experts in the field to bring state of art expertise and new clinical trials for BMF disorders to CHOP.
Daria Babushok, MD, PhD
Helge Hartung, MD
Dr. Hartung’s clinical efforts focus on pediatric non-malignant blood disorders, with a specific emphasis on the diagnosis and management of children with inherited and acquired bone marrow failure syndromes.
Peter Kurre, MD
With extended training in Pediatric Hematology, Oncology and Stem Cell Transplantation at Fred Hutchinson Cancer Research Center, Dr. Kurre’s clinical work is now focused on children with bone marrow failure. He strives to provide excellence in care for families and patients across a wide spectrum of inherited and acquired conditions that lead to loss of blood formation. As a Physician Scientist, both clinical and scientific goals of his work are therefore directed at improving understanding and broadening treatment options for patients with bone marrow failure. Dr. Kurre’s laboratory has longstanding expertise in Fanconi Anemia (FA), a genetic condition with prominent hematologic complications. With training in transplantation and hematopoietic stem cell biology, he hopes to improve our understanding of the progressive hematopoietic failure in patients with BMF and FA, and broaden diagnostic approaches, and develop next generation therapies.
Timothy Olson, MD, PhD
Dr. Olson's clinical efforts focus on pediatric hematopoietic stem cell transplantation (HSCT), with a specific emphasis on HSCT for patients with inherited and acquired bone marrow failure.
As an administrator, Millicent provides coordination of research and clinical operations of the Center. Her duties include human resource functions, coordinating meetings, submitting employee reimbursements, approving invoices, managing budget, requesting IT support, and other administrative functions. Millicent also supports the Hematology/Oncology Fellowship Program and works closely with the Program Coordinator and Program Director with d
Beverly J. Paul is a graduate of St. Joseph’s Hospital School of Nursing. She has been a nurse for 43 years and a Children’s Hospital of Philadelphia employee for 39yrs. Her past experience has included Critical Care, Post Anesthesia Recovery, Sedation, & Radiology Nursing (particularly Interventional Radiology).
Joseph Oved, MD
Dr. Oved is a Pediatric Hematology/Oncology fellow and a postdoctoral fellow in Dr. Timothy Olson’s laboratory. His clinical interests involve hematopoietic stem cell transplant, cell therapies and bone marrow failure. He is currently working on developing novel lentiviral gene therapies for inherited bone marrow failure conditions.
Ji Zha, PhD
Dr. Ji Zha is a postdoctoral fellow in Dr. Timothy Olson’s laboratory. She is currently studying on the cellular and molecular roles of hematopoietic stem cell (HSC) niche in donor HSC engraftment following hematopoietic stem cell transplantation (SCT) in mouse models of inherited bone marrow failure, including Fanconi Anemia, Shwachman Diamond Syndrome, and Dyskeratosis Congenita.
Ding-Wen Chen, PhD
Dr. Chen completed his PhD at the University of Waterloo in 2018 with research training at the interface of drug delivery, gene therapy, nanomedicine and regenerative medicine. As a postdoctoral fellow at Kurre’s laboratory, Dr.
Jian-Meng Fan received her BS degree of Medical Laboratory from Shanghai JiaoTong University School of Medicine. She has extensive experience and skill sets in molecular and cellular biology, hematology, telomere biology and aging. She also has strong hands-on experience and record on patient-derived cell isolation, culturing and manipulation.
Lori Kunselman joined the Bone Marrow Failure Center in September 2014. As a research assistant, her role is to support Dr. Tim Olson in his research of engraftment efficiency in HSCT murine models. She is responsible for maintaining the conditional knockout mouse models of IGF and PDGF, as well as models of inherited bone marrow failure such as Fanconi Anemia, Shwachman Diamond Syndrome, and Dyskeratosis Congenita.
Caitlin Ritz received her Bachelors of Arts and Sciences in Biochemistry from the University of Colorado and completed a Post-Baccalaureate Specialized Studies Program at the University of Pennsylvania. She
Theresa Menna, BS, became a Research Technician for the Bone Marrow Failure Center in December 2018. Her role is to design and conduct experiments in tissue culture and mouse models to further understand the processes in hematopoietic stem cells that contribute to Fanconi Anemia.
Natasha received her Bachelor of Science degree in Biology from Haverford College in 2015. Natasha's previous research involved tracking chloroplast inheritance in Chlamydomonas with fluorescent protein tools and studying the effects of psychiatric drug therapies on glucocorticoid receptor translocation in human olfactory epithelial cells. Natasha's studies mechanisms of clonal evolution in acquired aplastic anemia.
Peter Nicholas joined the Bone Marrow Failure Center in June of 2010 and is currently the Study Coordinator/Lab Manager. Peter oversees all the current IRB approved studies that are open within the Bone Marrow Failure Center, and makes sure they continue to be IRB compliant.
Millicent, Mentor and Inspiration
Wednesday, April 17, 2019 Full Article: view
A stalwart of the CBMFC program, Millicent has been a Program member since 2011 and Fiscal Manager since 2015. We all know she is a hardcore Eagles fan, but not everyone knows about the true breadth of Millicent’s interests beyond her responsibilities to the CBMFC and Peds Hem/Onc Fellowship programs: CHOP Bioresponse Team member, CHOP Multicultural Professional Network member and Spark Mentor.
About Our Center/History
Tuesday, February 12, 2019 Full Article: view
The Children’s Hospital of Philadelphia/University of Pennsylvania Comprehensive Bone Marrow Failure Center (CBMFC) was established in 2010 by Dr. Monica Bessler, M.D. Ph.D., an internationally recognized Physician-Scientist with expertise in numerous bone marrow failure (BMF) syndromes including dyskeratosis congenita, aplastic anemia, and paroxysmal nocturnal hemoglobinuria. Dr. Bessler defined the mission of the CBMFC as having two goals:
Peter Kurre, MD, Appointed Director of the Comprehensive Bone Marrow Failure Center
Wednesday, January 30, 2019 Full Article: view
Peter Kurre, MD, joined Children’s Hospital of Philadelphia (CHOP) as Director of the Comprehensive Bone Marrow Failure Center on August 31, 2018. In collaboration with bone marrow failure (BMF) experts at the Perelman School of Medicine at the University of Pennsylvania, the center has built an international reputation of excellence in consultation and treatment of patients with BMF disorders, currently following well over 200 patients. Dr. Kurre will lead a world-renowned, multidisciplinary team in developing new therapies for BMF syndromes and in basic research to understand the causes of these syndromes.
Thursday, June 13, 2019 Full Article: view
Following his Thesis Defense at the University of Waterloo, Roger joined our group in February of this year. For his post doc, he has taken the lead on helping us understand the role EVs play in regulating hematopoietic stem cells. He has made steady progress in getting experimental systems in place and validating approaches for studying HSC and EVs, when his Graduate Studies caught up with him recently: Roger was awarded with the "W.B. Pearson Medal" for his PhD thesis work!